Abstract: To study the physiological response by the pressure developed by foundation garment,the wearing experimental procedure was designed and fifteen female undergraduates were employed as subjects.The physical response according to the clothing pressure from seven representative physiological variables(oxygen uptake,respiratory exchange rate,heart rate etc.) was investigated.And from the result we obtained that fitness and coverage position was the main factors affecting physiological response.Relationships between clothing pressure at each point of body surface during exercise and physiological variables were further explored,and found that the factor of respiratory before exercise has correlation with pressure of the area above the waist and bust,the factor of heart rate before exercise has no significant correlation with pressure of every point,but the factor of respiratory during exercise has a significant correlation with the pressure of bust area,the factor of heart rate during exercise also has a significant correlation with the pressure of front waist area during riding ergonomic bike exercise.