Abstract: To investigate the effect of different core-sheath thickness ratios of core-sheath TiO2/ZnO nanofibers on the photoelectric performance of dye sensitized solar cell, core-sheath TiO2/ZnO nanofibers with different thickness ratios was fabricated by coaxial electrospinning via controlling spinning core-sheath solution flow rate ratios. Field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray diffraction (XRD) were used to characterize the core-sheath nanofibers. The results revealed that the nanofiber is composed of wurtzite ZnO as sheath and anatase TiO2 as core. Then, the TiO2/ZnO core-sheath nanofibrous membranes acted as photo-anode material to assemble dye sensitized solar cells. At last, we found that when the skin core spinning flow rate ratio is 1:1, the diameter of core-sheath nanofibers is about 154 nm and core layer is about 90 nm in diameter，the dye adsorption amount is the largest and the DSSC based on the core-sheath nanofibers has the highest efficiency of 5.47%, it is 22% higher comparing with DSSC based on the TiO2 nanofibers.