Abstract: In order to develop high quality and functional cotton product, sericin with negative charge and chitosan derivative with positively charged were reacted to form a new micro particles with viscose effect in aqueous solution, sericin was further fixed on cotton fabric by polyacrylic acid crosslinking agent reacted at low temperature. The wearability, surface morphology and structure and others were tested of cotton fabrics before and after sericin coated finishing. The results showed that the sericin was successfully coated uniformly on the surface of cotton fabric, and good washing durability. The dissolve loss rate of sericin coated fabric is about 0.21% after five washing cycles.The moisture absorption, thermal insulation, moisture permeability and biocidal property of sericin coated cotton fabric increased, but the air permeability almost did not change .The sericin coated cotton fabric was a new kind of top grade cotton products.