Abstract: For analyzing the application of tannic acid-cellulose acetate composite nanofiber in medical materials,using electrospinning technology ,deposit cellulose acetate(CA) nanofiber with mass fraction of 11% and TA/CA composite nanofiber which mass fraction of TA is 1%,3%,5% separately on the medical gauze to prepare sandwich structure in the style of gauze-namofiber-gauze .Testing TA release performance in the condition of different fraction,different tempretures,different PBS and different structures,then study the release kinetics of TA.Result shows that the release rate of TA increases as the TA fraction increases,higher tempreture contributes to the release rate of TA;pH value influnces the TA release performance that accumulative release amount decreases when in acidic condition as well as the rate,Compares to sole nanofiber,the sandwich structure materials have a better control effect;and the TA release performence fits Ritger-Peppas kinetics model.

Key words: electrospinning, composite nanofiber, sandwich structure, tannic acid, controlled-release