纺织学报 ›› 2009, Vol. 30 ›› Issue (04): 1-4.

• 纤维材料 •    下一篇

静电纺丝制备阿昔洛韦载药超细纤维垫

张晓飞;余灯广; 朱思君;申夏夏; Chris Branford-White ;朱利民   

  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-04-15 发布日期:2009-04-15

Investigation of electrospun acyclovir-loaded ultrafine fiber mats

ZHANG Xiaofei; YU Dengguang; ZHU Sijun; SHEN Xiaxia; Chris Branford-White;ZHU Limin   

  • Received:1900-01-01 Revised:1900-01-01 Online:2009-04-15 Published:2009-04-15

摘要: 采用高压静电纺丝技术制备载有阿昔洛韦的聚丙烯腈(PAN)超细纤维垫并对其进行表征。扫描电子显微镜观察结果表明,随着载药量增加,纤维直径呈增大趋势,当阿昔洛韦与PAN的质量比为20:100时,纤维中有少量药物颗粒析出;红外扫描结果表明阿昔洛韦与PAN之间具有较好相容性;体外溶出试验结果表明,载药纤维垫有明显的初期突释现象,随着载药量增加,初期突释更加明显,而药物释放度相应提高。不同载药量的纤维垫均能控制药物通过扩散机制缓慢释放60%以上的药物。静电纺丝载药纤维垫可为制备新型透皮给药系统或皮肤局部给药系统的研究开发提供新策略。

Abstract: Medicated ultrafine fiber mats were prepared using electrospinning with polyacrylonitrile (PAN) as matrix and acyclovir as model drug. The mats were characterized by scanning electron microscope (SEM), infrared spectroscopy (IR) and in vitro dissolution tests. SEM images envisaged that the diameters of fibers increased slightly with the increase of acyclovir contents in the fibers, and that fine drug particles were observed clearly on the fiber surface when the ratio in weight of acyclovir to PAN was 20 to 100. IR spectra results showed that that acyclovir had fine compatibility with PAN. In vitro dissolution tests indicated that the initial burst effects were obvious, and even more manifest when the content of acyclovir in the fibers increased, and meanwhile the total drug release percentage increased. All the ultrafine fiber mats were able to control the release of over 60% of acyclovir sustainedly via diffusion mechanism. Electrospun medicated fiber mats may offer novel strategies for the research and development of transdermal drug delivery systems or topical drug delivery systems.

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