Abstract: The nanoparticles with antimicrobial, anti-ultraviolet, far-infrared and antistatic properties were introduced. The methods and developments of fabricating functional fibers containing nanoparticles by electrospinning and melt spinning were reviewed. Electrospinning methods include blend spinning and in-situ synthesis of the nanoparticles, and melt spinning methods include blend spinning and in-situ polymerization. The size and dispersion of the nanoparticles will significantly influence the spinnability and properties of the fibers, and the nanoparticles can dispersed in the electrospun fibers without agglomeration by in-situ synthesis.