2类阳离子表面活性剂对细胞增殖抑制作用

纺织学报 ›› 2013, Vol. 34 ›› Issue (10): 112-0.

2类阳离子表面活性剂对细胞增殖抑制作用

魏华王晓宁廖青

北京服装学院材料科学与工程学院

收稿日期:2012-08-21 修回日期:2013-02-19 出版日期:2013-10-15 发布日期:2013-10-10
通讯作者: 廖青 E-mail:clylqq@bift.edu.cn
基金资助:
北京市属高等学校人才强教计划资助项目;服装材料研究开发与评价北京市重点实验室开放课题资助项目

Study of proliferation inhibiting effect of two kinds of cationic surfactants on cells

Received:2012-08-21 Revised:2013-02-19 Online:2013-10-15 Published:2013-10-10

摘要/Abstract

摘要： 通过噻唑蓝(MTT)比色法检测了四种单长链烷基三甲基氯化铵和三种单长链烷基二甲基苄基氯化铵系列阳表面活性剂对人宫颈癌细胞(HeLa) 及中华仓鼠卵巢细胞(CHO)的细胞增殖抑制作用，探讨两类结构相关的物质对细胞毒性的大小。结果表明: 单长链烷基三甲基氯化铵和单长链烷基二甲基苄基氯化铵对细胞的增殖抑制率均随其浓度的增大而增大；这两类物质的细胞增殖抑制作用均随其脂肪链长度的增加而增强；单长链烷基三甲基氯化铵的细胞毒性小于相同脂肪链长度的单长链烷基二甲基苄基氯化铵。

关键词: 单长链烷基三甲基氯化铵, 单长链烷基二甲基苄基氯化铵, CHO细胞, HeLa细胞, MTT法, 增殖抑制

Abstract: MTT assays is adopted to study of proliferation inhibiting effect of four kinds of alkyls trimethyl ammonium chloride and three kinds of alkyls dimethyl benzyl ammonium chloride on HeLa cells and CHO cells , and to discuss cytotoxicity of two kinds of cationic surfactants which are structurally related. The results indicated that the proliferation inhibiting effect of alkyls trimethyl ammonium chloride and alkyls dimethyl benzyl ammonium chloride on both HeLa cells and CHO cells gradually increased with con-centration increased；Proliferation inhibiting effect of Both these two kinds increased with the number of carbons increased.Cytotoxi-city of alkyls trimethyl ammonium chloride is lower than alkyls dimethyl benzyl ammonium chloride.

Key words: alkyl trimethyl ammonium chloride, alkyl dimethyl benzyl ammonium chloride, CHO cells, HeLa cells, MTT-assay, proliferation inhibition

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魏华王晓宁廖青. 2类阳离子表面活性剂对细胞增殖抑制作用[J]. 纺织学报, 2013, 34(10): 112-0.

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