Journal of Textile Research ›› 2020, Vol. 41 ›› Issue (07): 15-22.doi: 10.13475/j.fzxb.20191000408

• Fiber Materials • Previous Articles     Next Articles

Construction and drug release properties of fiber-based mesoporous SiO2 drug carrier

DUAN Hongmei, WANG Ximing, HUANG Zixin, GAO Jing(), WANG Lu   

  1. College of Textiles, Donghua University, Shanghai 201620, China
  • Received:2019-10-08 Revised:2020-01-20 Online:2020-07-15 Published:2020-07-23
  • Contact: GAO Jing E-mail:gao2001jing@dhu.edu.cn

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Abstract:

In order to study the drug releasing performance of fiber-based mesoporous SiO2, mesoporous SiO2 nanoparticles was prepared using sol-gel method, and the polycaprolactone (PCL) fiber membranes loaded with mesoporous SiO2 nanoparticles were prepared by electrospinning. The antibacterial drug ciprofloxacin hydrochloride was loaded into mesoporous SiO2 nanoparticles, and the releasing properties and releasing mechanism of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes were investigated under acidic conditions. The results show that the formation of mesoporous SiO2 nanoparticles is greatly affected by pH value. Within the moldable range, the particle size of the nanoparticles increases with increasing pH value. As the proportion of mesoporous SiO2 nanoparticles increases, the fineness of PCL composite fibers gradually decreases. The release of ciprofloxacin hydrochloride in individual nanoparticles and composite fiber membranes has a large initial release rate and a slow release in the later stage, the cumulative release rate in the two carriers within 12 h reaches 55.51% and 16.53%, respectively. The results of kinetic studies on the two drug release models indicate that diffusion is the main mechanism of drug release.

Key words: mesoporous silica, nanofiber membrane, ciprofloxacin hydrochloride, drug loading, drug release

CLC Number: 

  • TS101.4

Fig.1

TEM images of MSNs obtained by reaction at different pH value"

Fig.2

FT-IR spectra of MSNs before and after calcination at 550 ℃"

Fig.3

SAXD pattern of MSNs"

Fig.4

N2 adsorption-desorption isotherms(a) and pore size distribution of MSNs(b)"

Fig.5

Standard curve of Cip in aqueous solution(a) and in pH=5.4 PBS buffer(b)"

Fig.6

Effect of drug solution concentration on encapsulation efficiency and drug loading of MSNs"

Fig.7

SEM images of Cip-MSNs/PCL composite fiber membrane with different MSNs mass fraction"

Fig.8

EDX analysis of Cip-MSNs/PCL composite fiber membrane. (a) Distribution of Si; (b)Distribution of F"

Fig.9

In vitro release profile of Cip in different drug carriers"

Fig.10

Fitting of kinetic model of drug Cip release in different carriers"

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