Abstract: PLLA/FU composite nanofiber membranes were prepared by electrospinning. mass fraction of PLLA,ratio of Fluorouracil and spinning voltage were discussed. The mechanical properties and surface wettability were also studied. The results showed the diameters of the composite nanofiber membranes were increased with the increase of PLLA mass fraction, the diameters decreased with the increase of ratio of Fluorouracil. The mechanical performance testing showed the tensile strength , the elongation and rupture work of the composite were all less than PLLA nanofiber membranes, with the increase of the FU content ,these p erformances were more weaker .The wetting property testing showed the wettability of the composite were increased with the addition of the drug, but their heterogeneity were also increased.