Abstract: In this thesis, PVDF hollow fibers blood separate membrane are fabricated by using dry-wet phase inversion method. The hydrophilic of membrane materials is improved by the introduction of polyvinyl alcohol (PVA) with glutaraldehyde cross-linking reaction in the casting solution. The concentration of PVDF, PEG and other effects can affect membrane performance. The results indicated that the modifications of PVDF blood separate membrane significantly increase hydrophilic and water flux, decrease protein adsorption and have better chemical stability. The contact angle decreased from 70.2。 to 54.5。, the amount of protein adsorption decreased from 92mg/m2 to 27mg/m2 while Pure water flux from 85.4L / (h . m2) -1 to 189.4 L / (h . m2) -1. The tensile and burst pressure of membrane increased while the water flux and pore size decreased with the concentration of PVDF. The mechanical performance of membrane material has little changed while the water flux increased with the concentration of PEG.

Key words: PVDF, dry-wet phase inversion method, hollow fiber membrane, performance of membrane