载药聚乳酸/丝素纳米纤维的制备及缓释性能

纺织学报 ›› 2012, Vol. 33 ›› Issue (11): 15-19.

载药聚乳酸/丝素纳米纤维的制备及缓释性能

蒋岩岩秦静雯钱伟伟傅佳佳王鸿博

生态纺织教育部重点实验室（江南大学）

收稿日期:2011-11-30 修回日期:2012-03-28 出版日期:2012-11-15 发布日期:2012-11-20
通讯作者: 王鸿博 E-mail:wxwanghb@163.com
基金资助:
中央高校基本科研业务费专项资金资助项目；教育部长江学者和创新团队发展计划资助项目

Preparation and sustained-release evalution of electrospun drug loaded polylactide/silk fibroin nanofibers

Received:2011-11-30 Revised:2012-03-28 Online:2012-11-15 Published:2012-11-20

摘要/Abstract

摘要： 将药物阿司匹林、聚乳酸(PLA)和丝素蛋白(SF)同时溶解在三氟乙酸、二氯甲烷（体积比7:3）的二元溶剂中，通过静电纺丝技术制备载药PLA/SF复合纳米纤维。借助扫描电镜观察纳米纤维形貌，利用红外光谱分析其成分，并用紫外分光光度计检测其释放在磷酸盐缓冲液中药物的吸光度，并计算其释药速率。结果表明：复合纤维的平均直径随着药粉质量分数的增高而减小且PLA和SF能很好的复合；SF质量分数为3%时复合纤维释药速率最大；释药速率随着药粉浓度的增大而加快。

关键词: 静电纺, 聚乳酸, 丝素, 药物缓释

Abstract: Drug loaded composite nanofibers of PLA/SF were prepared via electrospinning by dissolving aspirin,polylactide (PLA) and silk fibroin (SF) in binary solvent of trifluoroacetic acid and dichloromethane at a volume ratio of 7/3.The films were characterized by scanning electron microscope (SEM) and infrared spectroscopy (IR),and the absorbency of drug in PBS solution was detected by UV-visible spectroscopy, then counting the velocity of drug release.It was found that the average diameter of the blended nanofibers become fine with the content of drug increasing,PLA and SF can be composited very well and releasing rate reaches the maximum when containing SF with 3% and increases with the aspirin content growing.

Key words: electrospinning, polylactide, silk fibroin, controlled-release of drug

中图分类号:

TS 102.5

蒋岩岩秦静雯钱伟伟傅佳佳王鸿博. 载药聚乳酸/丝素纳米纤维的制备及缓释性能[J]. 纺织学报, 2012, 33(11): 15-19.

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