纺织学报 ›› 2020, Vol. 41 ›› Issue (01): 26-31.doi: 10.13475/j.fzxb.20190200306

• 纤维材料 • 上一篇    下一篇

载药聚偏氟乙烯伤口敷料的制备及其性能

吴倩倩1,2, 李珂1, 杨立双1, 付译鋆1,2(), 张瑜1,2, 张海峰1,2   

  1. 1.南通大学 纺织服装学院, 江苏 南通 226019
    2.南通大学 安全防护用特种纤维复合材料研发国家地方联合工程研究中心, 江苏 南通 226019
  • 收稿日期:2019-01-29 修回日期:2019-10-24 出版日期:2020-01-15 发布日期:2020-01-14
  • 通讯作者: 付译鋆
  • 作者简介:吴倩倩(1995—),女,硕士生。主要研究方向为非织造医用材料。
  • 基金资助:
    江苏省自然科学基金项目(BK20190927);江苏省博士后日常资助项目(2019Z104);南通大学大学生创新训练计划项目(2019111);南通市科技计划项目(MS12018005);南通大学人才引进科研启动项目(17R19)

Preparation and properties of drug-loaded polyvinylidene fluoride wound dressings

WU Qianqian1,2, LI Ke1, YANG Lishuang1, FU Yijun1,2(), ZHANG Yu1,2, ZHANG Haifeng1,2   

  1. 1. School of Textile and Clothing, Nantong University, Nantong, Jiangsu 226019, China
    2. National & Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection,Nantong University, Nantong, Jiangsu 226019, China
  • Received:2019-01-29 Revised:2019-10-24 Online:2020-01-15 Published:2020-01-14
  • Contact: FU Yijun

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摘要：

为获得轻薄柔软的伤口敷料,并使其具备优异的压电和抗菌性能,以聚偏氟乙烯(PVDF)为原料,掺杂不同质量分数的盐酸恩诺沙星(Enro),采用静电纺丝技术制备载药PVDF复合纳米纤维膜。分析了复合纳米纤维膜的形貌、化学结构对其压电性能、药物缓释和抗菌性能的影响。结果表明:PVDF质量分数为8%时,纤维平均直径为(753±128) nm,纤维网成膜良好,复合纳米纤维膜直径随着Enro质量分数的增加呈先增大后减小趋势;纺丝过程中PVDF由α晶型转变为β晶型,使纤维膜具备了压电性能,可产生9 mV的输出电压;当 Enro质量分数为15%时,纤维膜释药速度平稳、持续时间长且具备优异的抗菌性能,适合用作伤口敷料。

关键词: 伤口敷料, 聚偏氟乙烯, 恩诺沙星, 静电纺丝, 压电性能, 抗菌性能

Abstract:

With the aim of obtaining thin and soft wound dressings with excellent piezoelectric and antibacterial functions, drug-loaded (PVDF) composite nanofiber membranes were prepared by electrospinning from PVDF and enrofloxacin hydrochloride (Enro) at different mass ratios. The influence of morphology and chemical structure of the composite nanofiber membrane on its piezoelectricity, sustained release and antibacterial properties were investigated. Results show that in the situation where the mass ratio of PVDF was 8% and the average fiber diameter was(753±128) nm, the fiber membrane showed good web formation. It is revealed that the diameter of composite nanofiber increased and then decreased as the Enro mass fraction was incremented, and that the crystal structure of PVDF changed from α to β crystal phase after the process of electrospinning, leading to an excellent piezoelectric properties with a 9 mV output voltage. When the mass concentration of Enro was 15%, the drug-loaded PVDF composite nanofiber membrane exhibited a relatively stable and sustainable release and outstanding antibacterial performance. The drug-loaded PVDF composite nanofiber membrane is proven to be suitable for wound dressings.

Key words: wound dressings, polyvinylidene fluoride, enrofloxacin hydrochloride, electrospinning, piezoelectric property, antibacterial property

中图分类号: 

  • TS174.8

图1

不同质量分数PVDF纳米纤维膜的扫描电镜照片(×5 000)"

图2

不同Enro质量分数下PVDF/Enro复合纳米纤维膜的扫描电镜照片(×8 000)"

图3

PVDF粉末、Enro粉末、纯PVDF纳米纤维膜以及PVDF/Enro复合纳米纤维膜的红外光谱图"

图4

不同纤维膜及PVDF粉末的X射线衍射图"

图5

不同Enro质量分数下PVDF/Enro复合纳米纤维膜的输出电压"

图6

Enro标准曲线"

图7

PVDF/Enro复合纳米纤维膜体外模拟累计释放曲线"

图8

PVDF纳米纤维膜载药前后菌群密度"

[1] 谷世行, 肖丽玲. 壳聚糖及其衍生物在创口敷料中的应用研究新进展[J]. 现代医学与健康研究电子杂志 2017, 1(4):151-155.
GU Shixing, XIAO Liling. New progress in the application of chitosan and its derivatives in wound dressings[J]. Modern Medicine and Health Research, 2017, 1(4):151-155.
[2] 李晶, 薛斌. 新型医用敷料的分类及特点[J]. 中国组织工程研究, 2013,17(12):2225-2232.
LI Jing, XUE Bin. Classification and characteristics of new medical dressings[J]. China Tissue Engineering Research, 2013,17(12):2225-2232.
[3] 耿志杰, 陈军, 刘群峰, 等. 伤口护理应用医用湿性敷料研究进展[J]. 护理学报, 2017,24(11):27-30.
GENG Zhijie, CHEN Jun, LIU Qunfeng, et al. Research progress in wound care application for medical wet dressings[J]. Journal of Nursing(China), 2017,24(11):27-30.
[4] FU R, CHEN S, LIN Y, et al. Improved piezoelectric properties of electrospun poly(vinylidene fluoride) fibers blended with cellulose nanocrystals[J]. Materials Letters, 2017(15):86-88.
[5] WU C M, CHOU M H. Polymorphism piezoelectricity and sound absorption of electrospun PVDF membranes with and without carbon nanotubes[J]. Compos Sci, Technol, 2016,4(28):127-133.
[6] 李静静, 卢辉, 蒋洁, 等. 高压电性氧化锌/聚偏氟乙烯复合纤维膜[J]. 纺织学报, 2018,39(2):2-3.
LI Jingjing, LU Hui, JIANG Jie, et al. High piezoelectric zinc oxide/polyvinylidene fluoride composite fiber membrane[J]. Journal of Textile Research, 2018,39(2):2-3.
[7] 程慰. 离子液体对PVDF共混溶液相容性及成膜形貌结构的影响[D]. 广州:华南理工大学, 2013: 6-9.
CHENG Wei. Effect of ionic liquids on compatibility and film morphology of PVDF blends[D]. Guangzhou: South China University of Technology, 2013: 6-9.
[8] YCAY X M, LEI T P, SUN D H, et al. A critical analysis of the α、β and γ phases in poly(vinylidene fluoride) using FTIR[J]. RSC Advances, 2017,25:15383-15389.
[9] BIRANCHE Tandon, ADRIÁN Magaz, RICHARD Balint, et al. Electroactive biomaterials: vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration[J]. Advanced Drug Delivery Reviews, 2017,7(25):1-4.
doi: 10.1016/0169-409X(91)90046-F
[10] 封小玲. 不同处理方式对恩诺沙星体外溶出及抑菌性的影响[D]. 重庆:重庆大学, 2013: 13-17.
FENG Xiaoling. Effects of different treatments on in vitro dissolution and bacteriostasis of enrofloxacin[D]. Chongqing: Chongqing University, 2013: 13-17.
[11] 刘京强, 崔巍巍, 刘立柱, 等. 不同溶剂配比及后处理温度对电纺PVDF/PEI复合纤维薄膜β相含量的影响[J]. 功能材料, 2016,47(8):08222-08225.
LIU Jingqiang, CUI Weiwei, LIU Lizhu, et al. Effect of different solvent ratios and post-treatment temperatures on β phase content of electrospun PVDF/PEI composite fiber films[J]. Functional Materials, 2016,47(8):08222-08225.
[12] 王旋. 静电纺聚偏氟乙烯纳米纤维膜压电性能研究[D]. 上海:东华大学, 2015: 30-31.
WANG Xuan. Study on piezoelectric properties of electrospun polyvinylidene fluoride nanofiber membrane[D]. Shanghai: Donghua University, 2015: 30-31.
[13] 蒋洁, 陈胜, 李静静, 等. 静电纺钛酸钡/聚偏氟乙烯纳米复合柔性压电纤维膜[J]. 纺织学报, 2018,39(2):15-16.
JIANG Jie, CHEN Sheng, LI Jingjing, et al. Electrospun strontium titanate/polyvinylidene fluoride nanocomposite flexible piezoelectric fiber memb-rane[J]. Journal of Textile Research, 2018,39(2):15-16.
doi: 10.1177/004051756903900103
[14] 刘京强. 电纺PVDF/PET复合纤维薄膜的制备与性能研究[D]. 哈尔滨:哈尔滨理工大学, 2016: 35-36.
LIU Jingqiang. Study on preparation and properties of electrospun PVDF/PET composite fiber films[D]. Harbin: Harbin University of Science and Technology, 2016: 35-36.
[15] BORMASHENKO Y, POGREB R, STANEVSKY O. Vibrational spectrum of PVDF and itsinterpretation[J]. Polym Test, 2004,23:791-796.
doi: 10.1016/j.polymertesting.2004.04.001
[16] SALIMI A, YOUSEFI A A. Analysis method FTIR studies of phase crystal formationin stretched PVDF films[J]. Polym Test, 2003,22:699-704.
doi: 10.1016/S0142-9418(03)00003-5
[17] LAI S H, LIU F, ZHANG W. TiO2 nanotubes as animal drug delivery system andin vitro controlled release[J]. Nanosci Nanotechnol, 2013,13:91-97.
[18] MARTINS P, LOPES A C, MENMEZ S. Electroactive phases of poly(vinylidene fluoride): determination, processing and applications[J]. Progress in Polymer Science, 2014,39(4):683-706.
doi: 10.1016/j.progpolymsci.2013.07.006
[19] ESTERLY D M, LOVE B J. Phase transformation to beta-poly(vinylidenefluoride) by milling[J]. Journal of Polymer Science Part B: Polymer Physics, 2004,42(1):91-97.
doi: 10.1002/(ISSN)1099-0488
[20] SEYYED A H, SAEED G, MAJED A, et al. Phase transformation to beta-poly(vinylidenefluoride) by milling[J]. Science Direct, 2018,42(1):15710-15716.
[21] 程凤. 载药抗菌创伤敷料的制备与性能研究[D]. 上海:东华大学, 2015: 51-53.
CHENG Feng. Preparation and properties of drug-loaded antibacterial wound dressings[D]. Shanghai: Donghua University, 2015: 51-53.
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