Abstract: For improving the apocynum degumming process and the quality of degummed apocynum,the mathematical models of the biological degumming process of apocynum are established by utilizing the 3 factors′ central rotary experimental design of Box-Hunter.The objective is to present the principle of quality of degummed apocynum varies with biological technological parametersdegumming temperature,initial pH value,quantity of microbe on quantitative basis.The results show that the order of the contribution of all parameters to removing the gum of apocynum is initial pH value>interaction of initial pH value and degumming temperature>quantity of microbe>treating temperature.The mathematical model has great significance to researching biological degumming of apcocynum.