Abstract: For the purpose of prediction of dye uptake rate and improving the quality of dyed products and utilization of dyestuff,this paper,based on analyzing actual experimental data of dye uptake rate,determined the key factors influencing uptake rate as follows: the concentration of dyestuff,dyeing time and temperature.Then,a single characteristics model of relation between the three key factors and uptake rate was established.Finally,a prediction model of multivariate nonlinear regression was developed and more accurate prediction of dye uptake rate was realized with it.The results predicted by the model of multivariate nonlinear regression show in good agreement with actual values,and the feasibility and validity of this method have been verified by practical experimental observations.