Abstract: Poly(L-lactic acid) micro-fibers which have antibacterial activity were prepared via electro-spinning by adding antibacterial agent Triclocarban (TCC). The effect of solvent, mass concentration of TCC on the structure and morphology of electrospun TCC/PLA micro-fibers were investigated by scanning electron microscopy (SEM).The effect of mass concentration of antibacterial (TCC) on antibacterial property was investigated. The results revealed that, when the solvent of spinning were dichloromethane and polyethylene glycol (400), the dissolvability of TCC and the effect of electrospun TCC/PLA were better and the solvent ratio was CH2Cl2:PEG(400)=9:1(V:V). As the mass concentration of TCC increased from 0.1% to 0.6%, the structure of fibers mainly remained unchange and the diameter of fibers increased slightly. When Triclocarban was 0.5%, the inhibiting efficiency of the composite micro-fiber was 98.6% and 94.2% respectively against Staphylococcus aurous and Escherichia coli.

Key words: electro-spinning , PLA , micro-fiber , triclocarban , antibacterial activity