Journal of Textile Research ›› 2021, Vol. 42 ›› Issue (06): 46-50.doi: 10.13475/j.fzxb.20200705505

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• Fiber Materials • Previous Articles     Next Articles

Preparation and properties of thermal bonded fibrous artificial blood vessels

GUO Fengyun1,2(), GUO Ziyi1,2, GAO Lei1,2, ZHENG Linjing1,2   

  1. 1. College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China
    2. Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Hangzhou, Zhejiang 310018, China
  • Received:2020-07-22 Revised:2021-01-29 Online:2021-06-15 Published:2021-06-25

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Abstract:

In order to prepare small-diameter artificial blood vessels with excellent properties, polycaprolactone/polyurethane (PCL/PU) small-diameter artificial blood vessels were prepared by electrospinning technology combined with soaking and tubing-off method, aiming to achieve non-cytotoxicity, puncture resistance, certain porosity and excellent mechanical properties. By means of scanning electron microscope and universal mechanical tensile testing machine, the morphology and mechanical properties of the materials were characterized, and the porosity, cytotoxicity and puncture resistance of artificial blood vessels were studied. The results showed that by changing the size of the receiving roller and then dissolving the inner polyvinyl pyrrolidone, the small diameter artificial blood vessel with the inner diameters of 2, 3, and 5 mm can be obtained. By adjusting the composition ratio and thermal bonding microstructure, the mechanical strength of artificial blood vessels was improved to be 7 times higher compared to the pure PU, with excellent mechanical properties of transverse and longitudinal stretching. The cell viability and porosity of the artificial blood vessel were 94% and 72%, respectively, and the comparison with the commercial expanded polyterafluoroethylene scaffold showed non fluid leakage after puncture.

Key words: electrospinning, artificial blood vessel, thermal bonding point, mechanical enhancement, puncture resistance

CLC Number: 

  • TQ342.87

Fig.1

Preparation schematic of artificial blood vessel. (a) Electrospinning process; (b) Tubing-off process"

Fig.2

SEM images of fibrous film and artificial blood vessel. (a) PU fibrous film(×10 000); (b) PCL/PU fibrous film(×10 000); (c) PCL fibrous film(×10 000); (d) Inner layer of artificial blood vessel(×4 000); (e) Outer layer of artificial blood vessel(×4 000); (f) Cross-sectional of artificial blood vessel(×10 000)"

Fig.3

Mechanical properties of fibrous film(a) and artificial blood vessel(b)"

Fig.4

Vascular puncture experiment. (a) PCL/PU fibrous artificial blood vessel; (b) Commercial e-PTFE"

Fig.5

Cell viability according to a MTT assay"

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