纺织学报 ›› 2021, Vol. 42 ›› Issue (11): 1-8.doi: 10.13475/j.fzxb.20211003008

• 特邀论文 •    下一篇

生物3D打印用丝素蛋白基凝胶墨水的研究进展

姜雨淋1,2,3, 王卉1,2,3, 张克勤1,2,3()   

  1. 1.苏州大学 纺织与服装工程学院, 江苏 苏州 215021
    2.苏州大学 现代丝绸国家工程实验室, 江苏 苏州 215123
    3.苏州大学 纺织行业丝绸功能材料与技术重点实验室, 江苏 苏州 215123
  • 收稿日期:2021-10-01 修回日期:2021-10-15 出版日期:2021-11-15 发布日期:2021-11-29
  • 通讯作者: 张克勤
  • 作者简介:姜雨淋(1996—),女,硕士生。主要研究方向为生物材料。
  • 基金资助:
    国家自然科学基金面上项目(51873134);国家自然科学基金委员会与英国皇家学会合作交流项目(5181102121);江苏省高等学校自然科学研究重大项目(17KJA540002);江苏省自然科学基金面上项目(BK20211317);江苏省丝绸工程重点实验室开放课题(KJS1833)

Research progress of silk fibroin-based hydrogel bioinks for 3D bio-printing

JIANG Yulin1,2,3, WANG Hui1,2,3, ZHANG Keqin1,2,3()   

  1. 1. College of Textiles and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215021, China
    2. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China
    3. China National Textile and Apparel Council Key Laboratory of Silk Functional Materials and Technology, Soochow University, Suzhou, Jiangsu 215123, China
  • Received:2021-10-01 Revised:2021-10-15 Published:2021-11-15 Online:2021-11-29
  • Contact: ZHANG Keqin

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摘要：

丝素蛋白(SF)作为一种天然且古老的蛋白质材料,因其优异的特性成为了生物3D打印墨水材料绝佳的候选者,在生物医学领域受到了广泛的关注。为此,概述了SF在生物3D打印领域的发展,总结了SF材料的物理化学和生物学基本特性,探讨了其作为生物墨水应用于挤出式生物3D打印、光固化生物3D打印和喷墨生物3D打印的要求和可加工性。综述了近年来SF与人工合成聚合物、天然聚合物和无机功能材料复合形成SF基水凝胶墨水在生物3D打印领域中的研究进展,对其所面临的挑战进行了讨论。指出:随着生物3D打印技术的深入发展,通过生物3D打印形成的SF基水凝胶构建体在生物医学领域会有更广阔的应用前景。

关键词: 生物3D打印, 丝素蛋白, 生物墨水, 水凝胶, 生物相容性

Abstract:

As a natural and ancient protein material, silk fibroin (SF) has become an excellent candidate for 3D printing bioinks due to its excellent properties, and has received extensive attention in the biomedical field. The development of SF in the field of biological 3D printing is summarized, the basic physicochemical and biological characteristics of SF materials are mainly summarized, and the requirements and processability of SF materials as bio-inks for extrusion biological 3D printing, photocurable biological 3D printing and inkjet biological 3D printing are discussed. The research progress of SF based hydrogel inks synthesized with artificial polymers, natural polymers and inorganic functional materials in the field of biological 3D printing in recent years is reviewed, and the challenges are discussed. It is pointed out that with the further development of biological 3D printing technology, SF-based hydrogel constructs formed by biological 3D printing will have a broader application prospect in the biomedical field.

Key words: 3D bio-printing, silk fibroin, bioink, hydrogel, biocompatibility

中图分类号: 

  • TS101.4

图1

桑蚕丝的多层次结构"

图2

SF水凝胶的交联方式及其3D打印结构体在组织工程领域的应用"

图3

水凝胶生物墨水在生物3D打印中至关重要的影响因素及其相互关系示意图"

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