纺织学报 ›› 2022, Vol. 43 ›› Issue (12): 16-21.doi: 10.13475/j.fzxb.20211106106

• 纤维材料 • 上一篇    下一篇

三维多孔生物可降解聚合物人工食管支架的结构与力学性能

王曙东1,2,3()   

  1. 1.盐城工业职业技术学院 纺织服装学院, 江苏 盐城 224005
    2.苏州大学 纺织与服装工程学院, 江苏 苏州 215002
    3.江苏金麦穗新能源科技股份有限公司, 江苏 盐城 224000
  • 收稿日期:2021-11-11 修回日期:2022-02-27 出版日期:2022-12-15 发布日期:2023-01-06
  • 作者简介:王曙东(1983—),男,副教授,博士。主要研究方向为生物医用纤维材料。E-mail:sdwang1983@163.com。
  • 基金资助:
    江苏省自然科学基金面上项目(BK20201216);江苏高校青蓝工程项目(苏教师〔2018〕12号);江苏高校青蓝工程项目(苏教师〔2019〕3号)

Structure and mechanical properties of three-dimensional porous biodegradable polymer artificial esophageal scaffold

WANG Shudong1,2,3()   

  1. 1. School of Textile and Clothing, Yancheng Polytechnic College, Yancheng, Jiangsu 224005, China
    2. College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215002, China
    3. Jiangsu Jinmaisui New Energy Technology Co., Ltd., Yancheng, Jiangsu 224000, China
  • Received:2021-11-11 Revised:2022-02-27 Published:2022-12-15 Online:2023-01-06

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摘要：

为满足人工食管支架对材料结构与力学性能的要求,以聚乳酸(PLA)和聚乳酸-羟基乙酸共聚物(PLGA)为原材料、圆柱形聚四氟乙烯为模板、氯化钠为致孔剂,制备了三维多孔生物可降解聚合物人工食管支架,并对食管支架的形貌、微观结构及其力学性能进行表征。结果表明:制备的PLA和PLGA人工食管支架具有三维多孔结构,经乙醇处理后,食管支架的长度、管径和孔隙率均有一定程度的降低。PLA和PLGA三维多孔食管支架的微观结构为无定型结构,乙醇处理在一定程度上提升了2种食管支架的结晶度。PLA和PLGA食管支架的断裂强度和缝合强力分别为(2.68±0.46) MPa、(3.68±0.98) N和(1.53±0.21) MPa、(2.21±0.65) N,乙醇处理后,2种食管支架的拉伸强度和缝合强力均有一定程度提升。2种食管支架的缝合强力均超过了食管支架移植时支架所能承受的缝合强力。

关键词: 人工食管支架, 聚乳酸, 聚乳酸-羟基乙酸共聚物, 生物可降解, 结构, 力学性能

Abstract:

In order to meet the requirements of artificial esophageal scaffolds on material's structure and mechanical properties, three-dimensional porous biodegradable polymer artificial esophageal scaffolds were prepared with biodegradable polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA) as raw materials, cylindrical polytetrafluoroethylene as template and sodium chloride as porogen. Morphology, microstructure and mechanical properties were characterized. The results show that the PLA and PLGA artificial esophageal scaffolds have three-dimensional porous structure. After ethanol treatment, the length, diameter and porosity of the esophageal scaffolds decrease to a certain extent. Microstructure of PLA and PLGA three-dimensional porous esophageal scaffolds is amorphous. Ethanol treatment improves the crystallinity of the two esophageal scaffolds to a certain extent. The breaking strength and suture strength of the PLA and PLGA esophageal scaffolds are (2.68±0.46) MPa, (3.68±0.98) N and (1.53±0.21) MPa, (2.21±0.65) N, respectively. After ethanol treatment, the tensile strength and suture strength of these two esophageal scaffolds are improved to a certain extent. The suture strength of the two esophageal scaffolds exceeds the suture strength that the scaffolds could bear during esophageal scaffolds transplantation.

Key words: artificial esophageal scaffold, polylactic acid, polylactic acid-glycdic acid copolymer, biodegradability, structure, mechanical property

中图分类号: 

  • TS102.512

图1

三维多孔食管支架的形貌结构照片"

表1

三维多孔食管支架的结构尺寸"

样品编号 长度/cm 管径/mm 壁厚/mm 孔隙率/%
1# 10.0 9.9 2.2 69.3
2# 9.9 9.8 2.1 61.9
3# 9.9 10.1 1.8 65.6
4# 9.8 9.9 1.7 58.3

图2

三维多孔生物可降解聚合物人工食管支架的SEM照片"

图3

三维多孔食管支架的红外光谱"

图4

三维多孔食管支架的X射线衍射光谱"

图5

三维多孔食管支架的热性能"

表2

三维多孔食管支架的力学性能"

样品
编号		 断裂强
度/MPa		 断裂伸
长率/%		 弹性模
量/MPa		 缝合强
力/N
1# 2.68±0.46 38.56±3.35 6.95±0.35 3.68±0.98
2# 2.97±0.38 32.37±2.76 9.18±0.27 4.02±1.32
3# 1.53±0.21 46.79±4.21 3.27±0.23 2.21±0.65
4# 1.84±0.26 44.28±3.82 4.16±0.19 2.86±0.78
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