Journal of Textile Research ›› 2022, Vol. 43 ›› Issue (11): 9-15.doi: 10.13475/j.fzxb.20210806207

• Fiber Materials • Previous Articles     Next Articles

Preparation and properties of modified poly(lactide-co-glycolide) nano-scaled drug delivery system by collagen

WU Huanling1(), XIE Zhouliang1, WANG Yang1, SUN Wanchao1, KANG Zhengfang2, XU Guohua3   

  1. 1. College of Textile & Clothing, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China
    2. Yancheng Quanhang Technology Co., Ltd., Yancheng, Jiangsu 224056, China
    3. Yancheng Chuangneng New Shielding Material Co., Ltd., Yancheng, Jiangsu 224043, China
  • Received:2021-08-16 Revised:2022-05-22 Online:2022-11-15 Published:2022-12-26
  • Contact: WU Huanling E-mail:wuhuanlingok@126.com

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Abstract:

In order to improve the slow degradation rate of poly(lactic acid-glycolic acid copolymer) (PLGA) and improve the drug release performances of PLGA-based drug loading materials, collagen (Col) as the modified material and doxorubicin (DOX) as the drug model, PLGA/Col/DOX nanofibrous membranes were prepared by electrostatic spinning technology with PLGA as the substrate, which can be used as sustained-release material for local tumor treatment. Modification effect of collagen on the hydrophilicity-hydrophobicity, in-vitro degradation, drug release performance and cytocompatibility of PLGA-based drug delivery system was investigated. The results showed that the properties of PLGA/Col nanofibrous membranes with a mass ratio of 75/25 were the best. After modification by collagen, the contact angle of the nanofibrous membrane decreased from 93.5°to 51.5°, indicating significant improvement of hydrophilicity. In-vitro degradation experiments showed that the 30-day weight loss rates of the nanofibers before and after collagen modification were 3.5% and 19% respectively, suggesting that the addition of collagen could greatly improve the degradation of PLGA. In-vitro drug release experiments showed that the drug release rate was significantly increased after modification, which could effectively improve the defects of low drug release rate and low drug release amount of PLGA. Cytotoxicity experiments showed that collagen could improve the biocompatibility of PLGA and facilitate cell adhesion and proliferation.

Key words: electrospinning, poly(lactide-co-glycolide), collagen protein, drug delivery system, degradability

CLC Number: 

  • TQ342.87

Tab.1

Composition of spinning solution"

样品名称 DOX体积/mL Col体积/mL PLGA体积/ mL
PLGA 0 0 10.0
PLGA/Col 0 2.5 7.5
PLGA/DOX 1 0 10.0
PLGA/Col/DOX 1 2.5 7.5

Fig.1

SEM images of different nanofibrous membranes"

Tab.2

Mechanical properties of different nanofibrous membranes"

样品名称 拉伸强度/MPa 断裂伸长率/% 弹性模量/MPa
PLGA 5.22 44.7 180.3
PLGA/Col 5.02 63.6 133.4
PLGA/Col/DOX 3.91 46.5 114.6

Fig.2

Water contact angle images of different nanofibrous membranes"

Fig.3

FT-IR spectra of different materials"

Fig.4

Thermogravimetric curves of different nanofiber membranes"

Fig.5

Weight loss rate of PLGA and PLGA/Col nanofiber membranes after 30 d of degradation"

Fig.6

Drug release curve of PLGA/DOX and PLGA/Col/DOX nanofiber membranes"

Fig.7

Adhesion and proliferation of L929 cells on different nanofiber membranes"

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