Journal of Textile Research ›› 2021, Vol. 42 ›› Issue (11): 1-8.doi: 10.13475/j.fzxb.20211003008

• Invited Paper •     Next Articles

Research progress of silk fibroin-based hydrogel bioinks for 3D bio-printing

JIANG Yulin1,2,3, WANG Hui1,2,3, ZHANG Keqin1,2,3()   

  1. 1. College of Textiles and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215021, China
    2. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, Jiangsu 215123, China
    3. China National Textile and Apparel Council Key Laboratory of Silk Functional Materials and Technology, Soochow University, Suzhou, Jiangsu 215123, China
  • Received:2021-10-01 Revised:2021-10-15 Online:2021-11-15 Published:2021-11-29
  • Contact: ZHANG Keqin E-mail:kqzhang@suda.edu.cn

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Abstract:

As a natural and ancient protein material, silk fibroin (SF) has become an excellent candidate for 3D printing bioinks due to its excellent properties, and has received extensive attention in the biomedical field. The development of SF in the field of biological 3D printing is summarized, the basic physicochemical and biological characteristics of SF materials are mainly summarized, and the requirements and processability of SF materials as bio-inks for extrusion biological 3D printing, photocurable biological 3D printing and inkjet biological 3D printing are discussed. The research progress of SF based hydrogel inks synthesized with artificial polymers, natural polymers and inorganic functional materials in the field of biological 3D printing in recent years is reviewed, and the challenges are discussed. It is pointed out that with the further development of biological 3D printing technology, SF-based hydrogel constructs formed by biological 3D printing will have a broader application prospect in the biomedical field.

Key words: 3D bio-printing, silk fibroin, bioink, hydrogel, biocompatibility

CLC Number: 

  • TS101.4

Fig.1

Multi-level structure of mulberry silk. (a)Schematic diagram of multi-level structure of single mulberry silk; (b)Scanning electron microscope images of natural mulberry silk; (c)Schematic diagram of amino acid sequence in SF crystal region"

Fig. 2

Crosslinking of SF hydrogels and application of 3D-printed structures in tissue engineering"

Fig.3

Schematic diagram of the critical influencing factors and their relationship of hydrogel bio-ink in biological 3D printing"

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